2011

Ibrahim Jantan, Nurul Hikmah Harun, Abdi Wira Septama, Shahnaz Murad and MA Mesaik (2011). Inhibition of chemiluminescence and chemotatic activity of phagocytes in vitro by extracts of selected medicinal plants. Journal of Natural Medicines 65(2): 400-405

The extracts of Curcuma domestica L., Phyllanthus amarus Schum & Thonn and C. xanthorrhiza Roxb. were the samples producing the strongest oxidative burst of PMNs with luminol-based chemiluminescence, with IC50 values ranging from 0.5 to 0.7 lg/ml. For macrophage cells, the extracts which showed strong suppressive activity for luminol-based chemiluminescence were C. xanthorrhiza and Garcinia mangostana L. Among the extracts studied, C. mangga Valton & Vazsjip, Piper nigrum L. and Labisia pumila var. alata showed strong inhibitory activity on lucigenin-amplified oxidative burst of PMNs, with IC50 values ranging from 0.9 to 1.5 lg/ml. The extracts of Zingiber officinale Rosc., Alpinia galangal (L.) Willd and Averrhoa bilimbi Linn showed strong inhibition on the chemotaxic migration of cells, with IC50 values comparable to that of ibuprofen (1.5 lg/ml). The results suggest that some of these plants were able to modulate the innate immune response of phagocytes at different steps, emphasizing their potential as a source of new immunomodulatory agents.