Activities of GLP Section
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Single dose (acute) oral toxicity studies on rodents according to OECD TG 420.
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Repeated dose 28-day (sub-acute) oral toxicity studies on rodents according to OECD TG 407.
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Repeated dose 90-day (sub-chronic) oral toxicity studies on rodents according to OECD TG 408.
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Animal toxicology studies according to international guidelines -ICH, FDA, and EMA.
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Single dose (acute) oral toxicity studies on rats according to OECD TG 420 and 10 OECD-GLP Principles for Malaysian Herbal Monograph.
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Provide consultation and organise meetings with potential sponsors such as ministries, universities, pharmaceutical companies, and industries to conduct animal toxicology studies.
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Organise GLP Refresher Course yearly for NCRF Personnel and other general GLP courses for newly appointed and current NCRF personnel.
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Organise specialised animal training and competency evaluations -blood sampling, necropsy, histopathology, ophthalmological and more.
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Organise specialised GLP personnel role training and competency evaluations -Study Director, Quality Assurance, Study Personnel and more.
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Coordinate and facilitate surveillance inspections by CMA for the renewal of OECD-GLP certification of NCRF, IMR every 2 years.
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Coordinate and facilitate visits from local and international GLP facilities.
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Figure 1: Rat cage changing activity |
Figure 2: Rat feed and bedding storage |
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Figure 3: Process of weighing test items |
Figure 4: Process of diluting test item using diluent vehicles prior to animal dosing |
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Figure 5: Cage cleaning process in dirty washing area |
Figure 6: Biochemistry machine in analytical laboratory |
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Figure 7: Haematology machine in analytical laboratory |
Figure 8: Sectioning process using microtome |
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Figure 9: Pathologist reading histopathology slides using microscope |
Figure 10: Archivist performing archiving |
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Figure 11: GLP Refresher course conducted every year for NCRF Personnel
